Vanchalearm Banchasakjaroen
Prince of Songkla University, Thailand
Title: One-year results of half-dose photodynamic therapy versus one-third-dose photodynamic therapy in chronic or recurrent central serous chorioretinopathy
Biography
Biography: Vanchalearm Banchasakjaroen
Abstract
Objective: To compare the efficacy of half-dose photodynamic Therapy (PDT) and one-third-dose PDT in treatment in chronic or recurrence Central Serous Chorioretinopathy (CSC).
Methods: A retrospective review of chronic or recurrence CSC patients, who were treated with half-dose or one-third dose PDT for 12 months follow-up. Best-Corrected Visual Acuity (BCVA), Central Retinal Thickness (CRT) and resolution of Subretinal Fluid (SRF) at baseline, 1, 3, 6, and 12 months post PDT were assessed.
Results: 46 eyes and 20 eyes received half-dose and one-third dose PDT, respectively. The study shows non-inferiority of the one-third-dose PDT compared with half-dose PDT in BCVA improvement (0.10±0.04 vs. 0.17±0.04 LogMar, P=0.293) and CRT improvement (125.6±24.6 vs. 139.1±16.54 µm, P=0.652) at 12 months follow-up. The recurrence rates of SRF was significant higher in one-third-dose of PDT compared with half-dose PDT (40.0% vs. 15.2%, P=0.027) at 12 months follow-up.
Conclusion: One-third-dose PDT was non inferiority in BCVA and CRT improvement when compared with half-dose PDT. This study showed one-third-dose PDT was higher recurrence rate of disease.