Valerie Sloane Jones
RayBiotech, Inc., USA
Title: The application of protein array technology to investigations of ocular disease
Biography
Biography: Valerie Sloane Jones
Abstract
Eye-derived fluids including tears, aqueous humor and vitreous humor often contain molecular signatures of ocular disease states in particular cytokines, chemokines, growth factors, proteases and soluble receptors. However, the small quantities (<10 µl) of these fluids severely limit the detection of these proteins by traditional ELISA or western blot. To maximize the amount of information generated from the analysis of these low-volume specimens, we have developed several innovative protein array technologies to profile multiple protein expression levels in a semi-quantitative or quantitative manner. Such technologies have been employed in the study of many complex ocular diseases including diabetic retinopathy, glaucoma, age-related macular degeneration and keratoconus. Our system has demonstrated great promise in advancing our understanding of the molecular mechanisms of these diseases and in the development of clinically useful biomarkers or drug targets.
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